The Science of PDRN: Skincare’s Regeneration Secret
When it comes to advanced skincare ingredients, one name that’s been making waves in K-beauty is PDRN (Polydeoxyribonucleotide). While it might sound complex, PDRN is essentially a DNA-derived compound (usually from salmon or trout) that’s prized for its ability to help the skin repair and regenerate itself.
What Exactly Is PDRN?
PDRN is a sequence of DNA fragments that the body recognizes as building blocks for cellular repair. In medicine, it’s been used for wound healing and tissue regeneration. In skincare, it’s valued for its ability to:
Boost skin repair by stimulating cell growth and collagen production.
Improve elasticity and firmness by enhancing the skin’s natural healing response.
Soothe inflammation while supporting barrier recovery.
Reduce visible signs of aging like fine lines, uneven tone, and dullness.
Think of PDRN as a “reset button” for stressed, damaged, or aging skin.
Why K-Beauty Uses PDRN Differently
While PDRN is gaining popularity worldwide, Korean skincare brands have perfected its use through:
Synergistic formulas: Blending PDRN with hydrating actives like hyaluronic acid, niacinamide, or peptides for all-around rejuvenation.
Innovative delivery: Using lightweight ampoules, micro-needling patches, or sheet masks to maximize absorption into the skin.
Skin-first approach: Positioning PDRN as not just an anti-aging fix, but as a regular step for maintaining healthy, resilient skin.
PDRN Essentials
Some of Our Best Recommendations
medicube
Salmon DNA PDRN Pink Peptide Serum
REJURAN®
Turnover Ampoule, c-PDRN®
TOSOWOONG
PDRN Collagen Jelly Cream, 5,000ppm Salmon DNA PDRN
ANUA
PDRN Hyaluronic Acid 100 Moisturizing Cream
Keep In Mind: How to Use PDRN
Best for nighttime routines, when the skin is naturally repairing.
Pair with hydrators and barrier-strengthening creams for optimal results.
Use consistently for several weeks to see improvements in skin texture and resilience.
PDRN can be used in combination with other skincare ingredients without any side effects. You might see PDRN used in combination with other beneficial skincare!
With any skincare ingredient, ALWAYS do a test patch along your jawline or on the inner part of your elbow.
